ABSTRACT: In the course of the development and exploitation of particular uranium deposits, the mine waters chemistry changed depending upon the extent of infiltration area, the total volume of worked-out uranium ore, its mineralogical composition and also the achieved depth of mining. In the course of flooding the underground mine after its closure many important changes occur in the content of dissolved substances in waters that increases several times (uranium, radium, iron, and others). Mine waters of flooded former uranium mines thus represent, with reference to their considerable volumes, a significant source of uranium. We are presenting hydrogeological aspects of conceptual model of the mine waters intensive utilisation from flooded uranium mines as a source of uranium with an accompanying effect of shortening the time necessary for the purification of mine waters discharged into the river.